Whole Genome Sequencing (WGS) provides the most comprehensive map of an organism’s genetic make-up. Unlike targeted sequencing, WGS covers all corners of an organisms’ entire genome, which is possibly the most important molecular data.
Chromatin Immunoprecipitation (ChIP) is a classic experiment method to study the interactions between proteins and DNA.
Methylated DNA immunoprecipitation sequencing (MeDIP-Seq) or DNA immunoprecipitation sequencing (DIP-Seq) is commonly used to study 5mC or 5hmC modification. It uses anti-5-methylcytosine antibodies coupled to magnetic beads to select for genomic fragments that are methylated.
RNA-Seq facilitates the discovery of novel transcripts, identification of alternatively spliced genes, and detection of allele-specific expression.