Through PRENITA, Bioserve offers a range of prenatal and post-natal screening tests that provide accurate results with actionable insights, which help the clinician to analyze and provide the best outcome to the patients. PRENITA provides the most advanced Preimplantation Genetic Screening/Diagnosis (PGS/PGD), Non-Invasive Prenatal Screening Test (NIPT), Invasive Diagnostic testing… Read more
Non-invasive Prenatal Testing

Prenatal Testing and its importance: Chromosomal abnormalities in the foetus constitute one of the leading causes of stillbirth and birth of infants with malformations.

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Syndrome Incidence
Trisomy 21 1 in 800 births
Trisomy 13 1 in 10,000 newborns
Trisomy 18 1 in 6,000 live births
Turner syndrome 1 in 2,500 live female births
Klinefelter syndrome 1 in 500 – 1,000 baby boys
Triple X 1 in 1,000 newborn girls

Prenatal testing is important as it 

  • Identifies chromosomal abnormalities at a very early stage,
  • Enables the expecting parents in better management of healthcare conditions.
  • Early intervention.

PRENITA NIPT is a Non-Invasive Prenatal Screening Test (NIPT) performed on cell free DNA extracted from maternal blood. During pregnancy, DNA fragments from the baby in the amniotic fluid crosses the placenta and enters the mother’s bloodstream. PRENITA NIPT is performed on this DNA to check for genetic conditions such as presence of extra or missing chromosomes and small microdeletions that could affect the baby’s health. 

PRENITA NIPT IS:

  • Simple – Only requires 8-10ml of maternal blood sample
  • Safe – Noninvasive and safe for both mother and fetus
  • Early – Can be performed as early as 10th week of gestational age
  • Reliable – Higher sensitivity and specificity
  • Accurate – Comprehensive information on all the 46 chromosomes
  • Fast – Results are provided within 6-8 working days

PRENITA NIPT is ideal for expectant mothers with

  • Advanced Maternal Age
  • Positive personal or family history
  • Abnormal ultrasound findings
  • Positive maternal serum screen

Conditions tested in PRENITA NIPT:

  • Chromosomal Aneuploidies Screened:
    • Trisomy 13: Patau Syndrome
    • Trisomy 18: Edward Syndrome
    • Trisomy 21: Down Syndrome
    • XXY: Klinefelter Syndrome
    • X0: Turner Syndrome
    • XYY: Jacob Syndrome
    • XXX Syndrome
  • Microdeletions Screened:
    • DiGeorge Syndrome
    • 1p36 Deletion Syndrome
    • Angelman/Praderwilli Syndrome
    • Cri-du-chat Syndrome
    • Wolf Hirschhorn Syndrome

How do I arrange this test?

  1. Discuss with your healthcare provider
  2. Fill in the Test Request Form
  3. Your blood is collected in appropriate container provided by us

Follow up services offered by BioServe’s PRENITA

  • Personalized genetic counselling
  • Confirmatory test for pregnancies at risk

FAQ

PRENITA NIPT is a Non-Invasive Prenatal Screening Test oered by Bioserve. It’s simple, fast, reliable, and most importantly, it’s safe! As the name suggests, it’s a non-invasive test done to rule out any genetic issues the baby might have. Our genetic system consists of DNA, of which the baby receives one set from the mother and the other set from the father. During pregnancy, bits of the baby’s DNA enter the mother’s blood. Thus, by extracting the mother’s blood, these DNA bits from the baby can be identified and tested upon.

The normal genetic chromosomal number is 46. Aneuploidy is the presence of an abnormal number of chromosomes. Microdeletion involves chromosomal deletions that include several genes in a chromosome. PRENITA NIPT screens for chromosomal aneuploidies and PRENITA NIPT MD screens for chromosomal aneuploidies and 5 common microdeletions.

Chromosomal aneuploidies screened:

  • Trisomy 13: Patau Syndrome
  • Trisomy 18: Edward Syndrome
  • Trisomy 21: Down Syndrome
  • XXY: Klinefelter Syndrome
  • X0: Turner Syndrome
  • XYY: Jacob Syndrome
  • XXX Syndrome

Microdeletions screened:

  • DiGeorge Syndrome
  • 1p36 Deletion Syndrome
  • Angelman/Praderwilli Syndrome
  • Cri-du-chat Syndrome
  • Wolf Hirshhom Syndrome

The prime concern for a mother is that her child be born without any complications. NIPT tests help in doing just that. Though not necessary, these tests help clear any chance of doubt that an expecting parent might have. With close to 99% accuracy at as early as 10 weeks into gestation, these tests provide vital clues about any concerns that may arise.

NIPT is a screening test that provides a checklist and score card to the above mentioned genetic conditions (aneuploidy and microdeletion ). An indication of Low Risk or High Risk helps you to determine the next line of action to assess your baby’s condition. This may include further tests to examine and determine the issue.

NIPT does not screen for certain defects like open neural tube defects and cannot predict late pregnancy complications like pre-eclampsia. Thus, maternal serum screening or ultrasound cannot be avoided.

Down Syndrome is a condition wherein there is an extra set of chromosomes (3 copies of chromosome 21 instead of 2 copies) in the child. This kind of aneuploidy is a result of random errors during DNA replication, either at conception or during the initial stages of pregnancy. It is not an inherited genetic condition and thus cannot aect the second child.

It is a screening test and not a diagnostic test, and chromosomal abnormalities such as unbalanced translocations, deletions, and duplications cannot be detected by NIPT.

  • Early gestational age
  • Placental mosaicism
  • Maternal obesity
  • Multiple pregnancies and vanishing twins
  • Maternal conditions like mosaicism or malignant disease or transplantation

If the NIPT test reveals a High-Risk score, confirmatory testing on invasive samples (CVS and amniotic fluid) must be performed. Diagnostic tests like Microarray, QFPCR, and MLPA are also offered under PRENITA as follow-ups for NIPT.

Furthermore, we care about the overall wellbeing of an expectant mother, and thus provide personalized counseling for the mother to discuss results and its impacts on her baby. An expert team of dedicated counselors ensures that every doubt is cleared and help is provided.

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