Epigenetic Modifications: Their Role in iPSC Reprogramming and Differentiation
Classic epigenetic modifications include DNA methylation and histone modifications as well as more broadly chromatin accessibility and non-coding RNAs. Epigenetic mechanisms enable heritable changes in gene expression that occur without altering the underlying DNA sequence. The various epigenetic layers act to control DNA accessibility and chromatin structure, which defines transcription factor binding and downstream gene…